antidiabetic drugs metformin combination

What is the most important information I should know about metformin?
• A small number of people who have taken metformin have developed a seriouscondition called lactic acidosis that has been fatal in up to 50% of cases antidiabetic drugs metformin combination. Lactic acidosis has occurred most often in people whose kidneys were not workingproperly antidiabetic drugs metformin combination. Liver problems may also increase the risk of developing lactic acidosis antidiabetic drugs metformin combination. Stop taking metformin and call your doctor immediately if you experience a feelingof general discomfort or sickness; weakness; sore or aching muscles; troublebreathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplainedstomach upset (after the initial stomach upset that may occur at the start oftherapy with metformin); or the sudden development of a slow or irregular heartbeat antidiabetic drugs metformin combination. These may be signs of lactic acidosis antidiabetic drugs metformin combination.
• Avoid excessive alcohol intake while taking metformin antidiabetic drugs metformin combination. Together, alcoholand metformin may increase the risk of lactic acidosis and hypoglycemia antidiabetic drugs metformin combination.
• Metformin does not usually cause hypoglycemia (low blood sugar) antidiabetic drugs metformin combination. Nevertheless,hypoglycemia may occur, as a result of skipped meals, excessive exercise, oralcohol consumption antidiabetic drugs metformin combination. Know the signs and symptoms of low blood sugar, which includehunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating,tremor, and nausea antidiabetic drugs metformin combination. Carry candy or glucose tablets to treat episodes of lowblood sugar antidiabetic drugs metformin combination.

What is metformin?
• Metformin is used to regulate blood glucose (sugar) levels antidiabetic drugs metformin combination. Metforminworks in three ways: first, it reduces the amount of glucose produced by yourliver; second, it reduces the amount of glucose absorbed from food through yourstomach; and third, it makes the insulin that your body produces work betterto reduce the amount of glucose already in your blood antidiabetic drugs metformin combination.
• Metformin is used to treat non-insulin-dependent diabetes mellitus (NIDDMor Type II diabetes) antidiabetic drugs metformin combination.
• Metformin may also be used for purposes other than those listed in thismedication guide antidiabetic drugs metformin combination.

What should I discuss with my healthcare provider before taking metformin?
• Do not take metformin without first talking to your doctor if you
· have kidney disease;
· have liver disease;
· have congestive heart failure;
· have acute or chronic metabolic acidosis, including diabetic ketoacidosis;
· have had a heart attack or a stroke;
· have a serious infection, illness, or injury;
· need to have surgery;
· need to have x-rays or other procedures using injectable contrast agents;
· are dehydrated (have lost water from your body) due to diarrhea, vomiting,fever, heat stroke, decreased fluid intake, or any other cause;
· drink alcohol; or
· are 80 years of age or older and have not had your kidney functiontested antidiabetic drugs metformin combination.
• You may not be able to take metformin, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove antidiabetic drugs metformin combination.
• Metformin is in the FDA pregnancy category B antidiabetic drugs metformin combination. This means that it is unlikelyto harm an unborn baby antidiabetic drugs metformin combination. Usually, your doctor will want to prescribe insulinto control diabetes during pregnancy antidiabetic drugs metformin combination. Do not take metformin without first talkingto your doctor if you are pregnant antidiabetic drugs metformin combination.
• Metformin passes into breast milk and may affect a nursing baby antidiabetic drugs metformin combination. Do nottake metformin without first talking to your doctor if you are breast-feedinga baby antidiabetic drugs metformin combination.
• If you are over the age of 65 years, there may be an slight increasein the risk of developing lactic acidosis due to a natural decline in kidneyfunction with advancing age antidiabetic drugs metformin combination. A lower dose or special monitoring may be necessaryduring your treatment antidiabetic drugs metformin combination.

How should I take metformin?
• Take metformin exactly as directed by your doctor antidiabetic drugs metformin combination. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain the instructionsto you antidiabetic drugs metformin combination.
• Take each dose with a full glass of water antidiabetic drugs metformin combination.
• Take metformin with a meal to reduce nausea, diarrhea, and upset stomachthat may occur with metformin therapy antidiabetic drugs metformin combination. These symptoms may be more likely tooccur during the first few weeks of therapy antidiabetic drugs metformin combination.
• A decrease in vitamin B12 may also occur during metformin therapy antidiabetic drugs metformin combination. Yourdoctor may want to monitor your blood levels of vitamin B12 and you may needto take B12 supplements antidiabetic drugs metformin combination. A vitamin B12 deficiency may rarely cause anemia antidiabetic drugs metformin combination.
• Your doctor may want to monitor your blood sugar control and other factorswith regularly scheduled blood tests antidiabetic drugs metformin combination.
• Occasionally, inactive ingredients in the metformin extended-release(Glucophage XR) tablets may pass through your body undissolved and appear inthe stool as a soft mass antidiabetic drugs metformin combination. This is not harmful, and the medication has been absorbedby your body antidiabetic drugs metformin combination.
• Store metformin at room temperature away from moisture and heat antidiabetic drugs metformin combination.

What happens if I miss a dose?
• Take the missed dose as soon as you remember antidiabetic drugs metformin combination. However, if it is almosttime for your next dose, skip the missed dose and only take your next regularlyscheduled dose antidiabetic drugs metformin combination. Do not take a double dose antidiabetic drugs metformin combination.

What happens if I overdose?
• Seek emergency medical attention antidiabetic drugs metformin combination.
• An overdose of metformin is likely to cause lactic acidosis antidiabetic drugs metformin combination. Symptomsof lactic acidosis include a feeling of general discomfort or sickness; weakness;sore or aching muscles; trouble breathing; unusual drowsiness, dizziness orlightheadedness; unusual or unexplained stomach upset (after the initial stomachupset that may occur at the start of therapy with metformin); and the suddendevelopment of a slow or irregular heartbeat antidiabetic drugs metformin combination.

What should I avoid while taking metformin?
• Avoid excessive alcohol intake while taking metformin antidiabetic drugs metformin combination. Together, alcoholand metformin may increase the risk of lactic acidosis and hypoglycemia antidiabetic drugs metformin combination.
• Follow your diet, medication, and exercise routines very closely antidiabetic drugs metformin combination. Changingany of these things can effect your blood sugar levels antidiabetic drugs metformin combination.
• Tell your doctor or other health care provider that you are taking thismedication if you need to have surgery or x-ray procedures that require injectionof contrast agents antidiabetic drugs metformin combination. Treatment with metformin may need to be stopped for a shortperiod of time antidiabetic drugs metformin combination.
• Tell your doctor that you are taking metformin if you become ill, ifyou have a heart attack; if you have a stroke; if you develop congestive heartfailure; if you experience diarrhea, vomiting, fever, or dehydration from anycause; or if you decrease the amount of food or liquid in your normal diet antidiabetic drugs metformin combination. You may need to stop your treatment with metformin for a short amount of timeuntil you are feeling better antidiabetic drugs metformin combination.

What are the possible side effects of metformin?
• Stop taking metformin and seek emergency medical attention if you experiencean allergic reaction (difficulty breathing; closing of your throat; swellingof your lips, tongue, or face; or hives) antidiabetic drugs metformin combination.
• A small number of people who have taken metformin have developed a seriouscondition called lactic acidosis that has been fatal in up to 50% of cases antidiabetic drugs metformin combination. Lactic acidosis has occurred most often in people whose kidneys were not workingproperly antidiabetic drugs metformin combination. Liver problems may also increase the risk of developing lactic acidosis antidiabetic drugs metformin combination. Stop taking metformin and call your doctor immediately if you experience a feelingof general discomfort or sickness; weakness; sore or aching muscles; troublebreathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplainedstomach upset (after the initial stomach upset that may occur at the start oftherapy with metformin); or the sudden development of a slow or irregular heartbeat antidiabetic drugs metformin combination. These may be signs of lactic acidosis antidiabetic drugs metformin combination.
• Other, less serious side effects may be more likely to occur antidiabetic drugs metformin combination. Continueto take metformin and talk to your doctor if you experience
· nausea, vomiting, abdominal pain, or diarrhea at the start of therapy;
· abdominal bloating or increased gas production; or
· decreased appetite or changes in taste (metallic taste in your mouth) antidiabetic drugs metformin combination.
• Side effects other than those listed here may also occur antidiabetic drugs metformin combination. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome antidiabetic drugs metformin combination.

What other drugs will affect metformin?
• Before taking this medication, tell your doctor if you are taking anyof the following medications:
· a diuretic (water pill) such as furosemide (Lasix), bumetanide (Bumex),ethacrynic acid (Edecrin), torsemide (Demadex), amiloride (Midamor), triamterene(Dyazide, Maxzide, Dyrenium), spironolactone (Aldactone), hydrochlorothiazide(HydroDiuril), chlorothiazide (Diuril), chlorthalidone (Hygroton), indapamide(Lozol), metolazone (Zaroxolyn, Mykrox), and others;
· a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine(Compazine), promethazine (Phenergan), and others
· an estrogen (Premarin, Prempro, Ogen, and others) or birth controlpill (Ovral, Lo-Ovral, Ortho-Novum, Triphasil, Levlen, Tri-Levlen, Alesse, andothers)
· a calcium channel blocker such as nifedipine (Adalat, Procardia), verapamil(Calan, Verelan, Isoptin), diltiazem (Cardizem, Dilacor XR), felodipine (Plendil),bepridil (Vascor), amlodipine (Norvasc), and others;
· a steroid medication such as prednisone (Deltasone), methylprednisolone(Medrol), dexamethasone (Decadron), and others;
· a thyroid medication (Synthroid, Levoxyl, Levothroid, and others),
· digoxin (Lanoxin, Lanoxicaps);
· procainamide (Pronestyl);
· quinidine (Cardioquin, others);
· cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);
· morphine (Astramorph, MS Contin, Roxanol, and others);
· trimethoprim (Proloprim, Trimpex, Septra, Bactrim);
· phenytoin (Dilantin);
· isoniazid (Nydrazid); or
· nicotinic acid or niacin (Nicobid, Nicolar, others) antidiabetic drugs metformin combination.
• You may not be able to take metformin, or you may require a dosage adjustmentor special monitoring if you are taking any of the medicines listed above antidiabetic drugs metformin combination.
• Drugs other than those listed here may also interact with metformin oraffect your condition antidiabetic drugs metformin combination. Talk to your doctor and pharmacist before taking anyprescription or over-the-counter medicines antidiabetic drugs metformin combination.

Where can I get more information?
• Your pharmacist has more information about metformin written for healthprofessionals that you may read antidiabetic drugs metformin combination.

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