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What is the most important information I should know about metformin?
• A small number of people who have taken metformin have developed a seriouscondition called lactic acidosis that has been fatal in up to 50% of cases aussie cysters metformin and weightloss. Lactic acidosis has occurred most often in people whose kidneys were not workingproperly aussie cysters metformin and weightloss. Liver problems may also increase the risk of developing lactic acidosis aussie cysters metformin and weightloss. Stop taking metformin and call your doctor immediately if you experience a feelingof general discomfort or sickness; weakness; sore or aching muscles; troublebreathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplainedstomach upset (after the initial stomach upset that may occur at the start oftherapy with metformin); or the sudden development of a slow or irregular heartbeat aussie cysters metformin and weightloss. These may be signs of lactic acidosis aussie cysters metformin and weightloss.
• Avoid excessive alcohol intake while taking metformin aussie cysters metformin and weightloss. Together, alcoholand metformin may increase the risk of lactic acidosis and hypoglycemia aussie cysters metformin and weightloss.
• Metformin does not usually cause hypoglycemia (low blood sugar) aussie cysters metformin and weightloss. Nevertheless,hypoglycemia may occur, as a result of skipped meals, excessive exercise, oralcohol consumption aussie cysters metformin and weightloss. Know the signs and symptoms of low blood sugar, which includehunger, headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating,tremor, and nausea aussie cysters metformin and weightloss. Carry candy or glucose tablets to treat episodes of lowblood sugar aussie cysters metformin and weightloss.


What is metformin?
• Metformin is used to regulate blood glucose (sugar) levels aussie cysters metformin and weightloss. Metforminworks in three ways: first, it reduces the amount of glucose produced by yourliver; second, it reduces the amount of glucose absorbed from food through yourstomach; and third, it makes the insulin that your body produces work betterto reduce the amount of glucose already in your blood aussie cysters metformin and weightloss.
• Metformin is used to treat non-insulin-dependent diabetes mellitus (NIDDMor Type II diabetes) aussie cysters metformin and weightloss.
• Metformin may also be used for purposes other than those listed in thismedication guide aussie cysters metformin and weightloss.


What should I discuss with my healthcare provider before taking metformin?
• Do not take metformin without first talking to your doctor if you
· have kidney disease;
· have liver disease;
· have congestive heart failure;
· have acute or chronic metabolic acidosis, including diabetic ketoacidosis;
· have had a heart attack or a stroke;
· have a serious infection, illness, or injury;
· need to have surgery;
· need to have x-rays or other procedures using injectable contrast agents;
· are dehydrated (have lost water from your body) due to diarrhea, vomiting,fever, heat stroke, decreased fluid intake, or any other cause;
· drink alcohol; or
· are 80 years of age or older and have not had your kidney functiontested aussie cysters metformin and weightloss.
• You may not be able to take metformin, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove aussie cysters metformin and weightloss.
• Metformin is in the FDA pregnancy category B aussie cysters metformin and weightloss. This means that it is unlikelyto harm an unborn baby aussie cysters metformin and weightloss. Usually, your doctor will want to prescribe insulinto control diabetes during pregnancy aussie cysters metformin and weightloss. Do not take metformin without first talkingto your doctor if you are pregnant aussie cysters metformin and weightloss.
• Metformin passes into breast milk and may affect a nursing baby aussie cysters metformin and weightloss. Do nottake metformin without first talking to your doctor if you are breast-feedinga baby aussie cysters metformin and weightloss.
• If you are over the age of 65 years, there may be an slight increasein the risk of developing lactic acidosis due to a natural decline in kidneyfunction with advancing age aussie cysters metformin and weightloss. A lower dose or special monitoring may be necessaryduring your treatment aussie cysters metformin and weightloss.


How should I take metformin?
• Take metformin exactly as directed by your doctor aussie cysters metformin and weightloss. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain the instructionsto you aussie cysters metformin and weightloss.
• Take each dose with a full glass of water aussie cysters metformin and weightloss.
• Take metformin with a meal to reduce nausea, diarrhea, and upset stomachthat may occur with metformin therapy aussie cysters metformin and weightloss. These symptoms may be more likely tooccur during the first few weeks of therapy aussie cysters metformin and weightloss.
• A decrease in vitamin B12 may also occur during metformin therapy aussie cysters metformin and weightloss. Yourdoctor may want to monitor your blood levels of vitamin B12 and you may needto take B12 supplements aussie cysters metformin and weightloss. A vitamin B12 deficiency may rarely cause anemia aussie cysters metformin and weightloss.
• Your doctor may want to monitor your blood sugar control and other factorswith regularly scheduled blood tests aussie cysters metformin and weightloss.
• Occasionally, inactive ingredients in the metformin extended-release(Glucophage XR) tablets may pass through your body undissolved and appear inthe stool as a soft mass aussie cysters metformin and weightloss. This is not harmful, and the medication has been absorbedby your body aussie cysters metformin and weightloss.
• Store metformin at room temperature away from moisture and heat aussie cysters metformin and weightloss.


What happens if I miss a dose?
• Take the missed dose as soon as you remember aussie cysters metformin and weightloss. However, if it is almosttime for your next dose, skip the missed dose and only take your next regularlyscheduled dose aussie cysters metformin and weightloss. Do not take a double dose aussie cysters metformin and weightloss.


What happens if I overdose?
• Seek emergency medical attention aussie cysters metformin and weightloss.
• An overdose of metformin is likely to cause lactic acidosis aussie cysters metformin and weightloss. Symptomsof lactic acidosis include a feeling of general discomfort or sickness; weakness;sore or aching muscles; trouble breathing; unusual drowsiness, dizziness orlightheadedness; unusual or unexplained stomach upset (after the initial stomachupset that may occur at the start of therapy with metformin); and the suddendevelopment of a slow or irregular heartbeat aussie cysters metformin and weightloss.


What should I avoid while taking metformin?
• Avoid excessive alcohol intake while taking metformin aussie cysters metformin and weightloss. Together, alcoholand metformin may increase the risk of lactic acidosis and hypoglycemia aussie cysters metformin and weightloss.
• Follow your diet, medication, and exercise routines very closely aussie cysters metformin and weightloss. Changingany of these things can effect your blood sugar levels aussie cysters metformin and weightloss.
• Tell your doctor or other health care provider that you are taking thismedication if you need to have surgery or x-ray procedures that require injectionof contrast agents aussie cysters metformin and weightloss. Treatment with metformin may need to be stopped for a shortperiod of time aussie cysters metformin and weightloss.
• Tell your doctor that you are taking metformin if you become ill, ifyou have a heart attack; if you have a stroke; if you develop congestive heartfailure; if you experience diarrhea, vomiting, fever, or dehydration from anycause; or if you decrease the amount of food or liquid in your normal diet aussie cysters metformin and weightloss. You may need to stop your treatment with metformin for a short amount of timeuntil you are feeling better aussie cysters metformin and weightloss.


What are the possible side effects of metformin?
• Stop taking metformin and seek emergency medical attention if you experiencean allergic reaction (difficulty breathing; closing of your throat; swellingof your lips, tongue, or face; or hives) aussie cysters metformin and weightloss.
• A small number of people who have taken metformin have developed a seriouscondition called lactic acidosis that has been fatal in up to 50% of cases aussie cysters metformin and weightloss. Lactic acidosis has occurred most often in people whose kidneys were not workingproperly aussie cysters metformin and weightloss. Liver problems may also increase the risk of developing lactic acidosis aussie cysters metformin and weightloss. Stop taking metformin and call your doctor immediately if you experience a feelingof general discomfort or sickness; weakness; sore or aching muscles; troublebreathing, unusual drowsiness, dizziness or lightheadedness; unusual or unexplainedstomach upset (after the initial stomach upset that may occur at the start oftherapy with metformin); or the sudden development of a slow or irregular heartbeat aussie cysters metformin and weightloss. These may be signs of lactic acidosis aussie cysters metformin and weightloss.
• Other, less serious side effects may be more likely to occur aussie cysters metformin and weightloss. Continueto take metformin and talk to your doctor if you experience
· nausea, vomiting, abdominal pain, or diarrhea at the start of therapy;
· abdominal bloating or increased gas production; or
· decreased appetite or changes in taste (metallic taste in your mouth) aussie cysters metformin and weightloss.
• Side effects other than those listed here may also occur aussie cysters metformin and weightloss. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome aussie cysters metformin and weightloss.


What other drugs will affect metformin?
• Before taking this medication, tell your doctor if you are taking anyof the following medications:
· a diuretic (water pill) such as furosemide (Lasix), bumetanide (Bumex),ethacrynic acid (Edecrin), torsemide (Demadex), amiloride (Midamor), triamterene(Dyazide, Maxzide, Dyrenium), spironolactone (Aldactone), hydrochlorothiazide(HydroDiuril), chlorothiazide (Diuril), chlorthalidone (Hygroton), indapamide(Lozol), metolazone (Zaroxolyn, Mykrox), and others;
· a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine(Compazine), promethazine (Phenergan), and others
· an estrogen (Premarin, Prempro, Ogen, and others) or birth controlpill (Ovral, Lo-Ovral, Ortho-Novum, Triphasil, Levlen, Tri-Levlen, Alesse, andothers)
· a calcium channel blocker such as nifedipine (Adalat, Procardia), verapamil(Calan, Verelan, Isoptin), diltiazem (Cardizem, Dilacor XR), felodipine (Plendil),bepridil (Vascor), amlodipine (Norvasc), and others;
· a steroid medication such as prednisone (Deltasone), methylprednisolone(Medrol), dexamethasone (Decadron), and others;
· a thyroid medication (Synthroid, Levoxyl, Levothroid, and others),
· digoxin (Lanoxin, Lanoxicaps);
· procainamide (Pronestyl);
· quinidine (Cardioquin, others);
· cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);
· morphine (Astramorph, MS Contin, Roxanol, and others);
· trimethoprim (Proloprim, Trimpex, Septra, Bactrim);
· phenytoin (Dilantin);
· isoniazid (Nydrazid); or
· nicotinic acid or niacin (Nicobid, Nicolar, others) aussie cysters metformin and weightloss.
• You may not be able to take metformin, or you may require a dosage adjustmentor special monitoring if you are taking any of the medicines listed above aussie cysters metformin and weightloss.
• Drugs other than those listed here may also interact with metformin oraffect your condition aussie cysters metformin and weightloss. Talk to your doctor and pharmacist before taking anyprescription or over-the-counter medicines aussie cysters metformin and weightloss.


Where can I get more information?
• Your pharmacist has more information about metformin written for healthprofessionals that you may read aussie cysters metformin and weightloss.


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