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cox 2 inhibitors methotrexate
(meth oh TREX ate)
Dose Pack, Trexall

What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication cox 2 inhibitors methotrexate.
• Methotrexate may cause side effects that could be dangerous or life-threatening cox 2 inhibitors methotrexate. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment cox 2 inhibitors methotrexate. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others cox 2 inhibitors methotrexate. Notify your doctor immediately if you develop any of these symptoms cox 2 inhibitors methotrexate.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment cox 2 inhibitors methotrexate. Methotrexate is in the FDA pregnancy category X cox 2 inhibitors methotrexate. This meansthat it is known to cause birth defects in an unborn baby cox 2 inhibitors methotrexate. Methotrexate canaffect a baby both when a woman is treated and when a man is treated cox 2 inhibitors methotrexate. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment cox 2 inhibitors methotrexate. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment cox 2 inhibitors methotrexate.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor cox 2 inhibitors methotrexate. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects cox 2 inhibitors methotrexate. Discuss the use of aspirin and NSAIDs with yourdoctor cox 2 inhibitors methotrexate.
• Do not drink alcohol while taking methotrexate cox 2 inhibitors methotrexate.


What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body cox 2 inhibitors methotrexate. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others cox 2 inhibitors methotrexate. This is how methotrexate works in the treatment of cancerand psoriasis cox 2 inhibitors methotrexate. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis cox 2 inhibitors methotrexate.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis cox 2 inhibitors methotrexate.
• Methotrexate may also be used for purposes other than those listed inthis medication guide cox 2 inhibitors methotrexate.


What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease cox 2 inhibitors methotrexate.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above cox 2 inhibitors methotrexate.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment cox 2 inhibitors methotrexate. Methotrexate is in the FDA pregnancy category X cox 2 inhibitors methotrexate. This meansthat it is known to cause birth defects in an unborn baby cox 2 inhibitors methotrexate. Methotrexate canaffect a baby both when a woman is treated and when a man is treated cox 2 inhibitors methotrexate. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment cox 2 inhibitors methotrexate. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment cox 2 inhibitors methotrexate.
• Methotrexate may be harmful to a nursing infant cox 2 inhibitors methotrexate. Breast-feeding is notrecommended during treatment with methotrexate cox 2 inhibitors methotrexate.


How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication cox 2 inhibitors methotrexate.
• Take oral methotrexate exactly as directed by your doctor cox 2 inhibitors methotrexate. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you cox 2 inhibitors methotrexate.
• Take each oral dose with a full glass of water cox 2 inhibitors methotrexate.
• Methotrexate is also available as an injection cox 2 inhibitors methotrexate. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication cox 2 inhibitors methotrexate.
• Do not take more of this medication than is prescribed cox 2 inhibitors methotrexate. Too much methotrexatecan be dangerous, possibly resulting in death cox 2 inhibitors methotrexate. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen cox 2 inhibitors methotrexate. Follow yourdoctor's instructions cox 2 inhibitors methotrexate.
• It is important to take methotrexate regularly to get the most benefit cox 2 inhibitors methotrexate.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects cox 2 inhibitors methotrexate.
• Store methotrexate at room temperature away from moisture and heat cox 2 inhibitors methotrexate.


What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate cox 2 inhibitors methotrexate.


What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected cox 2 inhibitors methotrexate.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath cox 2 inhibitors methotrexate.


What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor cox 2 inhibitors methotrexate. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects cox 2 inhibitors methotrexate. Discuss the use of aspirin and NSAIDs with yourdoctor cox 2 inhibitors methotrexate.
• Do not drink alcohol while taking methotrexate cox 2 inhibitors methotrexate.
• Avoid prolonged exposure to sunlight cox 2 inhibitors methotrexate. Methotrexate may increase the sensitivityof the skin to sunlight cox 2 inhibitors methotrexate. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable cox 2 inhibitors methotrexate.


What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening cox 2 inhibitors methotrexate. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment cox 2 inhibitors methotrexate. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others cox 2 inhibitors methotrexate. Notify your doctor immediately if you develop any of these symptoms cox 2 inhibitors methotrexate.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures cox 2 inhibitors methotrexate.
• Other, less serious side effects may be more likely to occur cox 2 inhibitors methotrexate. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision cox 2 inhibitors methotrexate.
• Side effects other than those listed here may also occur cox 2 inhibitors methotrexate. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome cox 2 inhibitors methotrexate.


What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor cox 2 inhibitors methotrexate. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects cox 2 inhibitors methotrexate.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others cox 2 inhibitors methotrexate.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove cox 2 inhibitors methotrexate.
• Drugs other than those listed here may also interact with methotrexate cox 2 inhibitors methotrexate. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products cox 2 inhibitors methotrexate.


Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read cox 2 inhibitors methotrexate.

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