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description of methotrexate tablets 25 mg
(meth oh TREX ate)
Dose Pack, Trexall

What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication description of methotrexate tablets 25 mg.
• Methotrexate may cause side effects that could be dangerous or life-threatening description of methotrexate tablets 25 mg. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment description of methotrexate tablets 25 mg. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others description of methotrexate tablets 25 mg. Notify your doctor immediately if you develop any of these symptoms description of methotrexate tablets 25 mg.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment description of methotrexate tablets 25 mg. Methotrexate is in the FDA pregnancy category X description of methotrexate tablets 25 mg. This meansthat it is known to cause birth defects in an unborn baby description of methotrexate tablets 25 mg. Methotrexate canaffect a baby both when a woman is treated and when a man is treated description of methotrexate tablets 25 mg. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment description of methotrexate tablets 25 mg. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment description of methotrexate tablets 25 mg.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor description of methotrexate tablets 25 mg. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects description of methotrexate tablets 25 mg. Discuss the use of aspirin and NSAIDs with yourdoctor description of methotrexate tablets 25 mg.
• Do not drink alcohol while taking methotrexate description of methotrexate tablets 25 mg.

What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body description of methotrexate tablets 25 mg. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others description of methotrexate tablets 25 mg. This is how methotrexate works in the treatment of cancerand psoriasis description of methotrexate tablets 25 mg. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis description of methotrexate tablets 25 mg.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis description of methotrexate tablets 25 mg.
• Methotrexate may also be used for purposes other than those listed inthis medication guide description of methotrexate tablets 25 mg.

What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease description of methotrexate tablets 25 mg.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above description of methotrexate tablets 25 mg.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment description of methotrexate tablets 25 mg. Methotrexate is in the FDA pregnancy category X description of methotrexate tablets 25 mg. This meansthat it is known to cause birth defects in an unborn baby description of methotrexate tablets 25 mg. Methotrexate canaffect a baby both when a woman is treated and when a man is treated description of methotrexate tablets 25 mg. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment description of methotrexate tablets 25 mg. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment description of methotrexate tablets 25 mg.
• Methotrexate may be harmful to a nursing infant description of methotrexate tablets 25 mg. Breast-feeding is notrecommended during treatment with methotrexate description of methotrexate tablets 25 mg.

How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication description of methotrexate tablets 25 mg.
• Take oral methotrexate exactly as directed by your doctor description of methotrexate tablets 25 mg. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you description of methotrexate tablets 25 mg.
• Take each oral dose with a full glass of water description of methotrexate tablets 25 mg.
• Methotrexate is also available as an injection description of methotrexate tablets 25 mg. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication description of methotrexate tablets 25 mg.
• Do not take more of this medication than is prescribed description of methotrexate tablets 25 mg. Too much methotrexatecan be dangerous, possibly resulting in death description of methotrexate tablets 25 mg. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen description of methotrexate tablets 25 mg. Follow yourdoctor's instructions description of methotrexate tablets 25 mg.
• It is important to take methotrexate regularly to get the most benefit description of methotrexate tablets 25 mg.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects description of methotrexate tablets 25 mg.
• Store methotrexate at room temperature away from moisture and heat description of methotrexate tablets 25 mg.

What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate description of methotrexate tablets 25 mg.

What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected description of methotrexate tablets 25 mg.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath description of methotrexate tablets 25 mg.

What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor description of methotrexate tablets 25 mg. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects description of methotrexate tablets 25 mg. Discuss the use of aspirin and NSAIDs with yourdoctor description of methotrexate tablets 25 mg.
• Do not drink alcohol while taking methotrexate description of methotrexate tablets 25 mg.
• Avoid prolonged exposure to sunlight description of methotrexate tablets 25 mg. Methotrexate may increase the sensitivityof the skin to sunlight description of methotrexate tablets 25 mg. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable description of methotrexate tablets 25 mg.

What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening description of methotrexate tablets 25 mg. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment description of methotrexate tablets 25 mg. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others description of methotrexate tablets 25 mg. Notify your doctor immediately if you develop any of these symptoms description of methotrexate tablets 25 mg.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures description of methotrexate tablets 25 mg.
• Other, less serious side effects may be more likely to occur description of methotrexate tablets 25 mg. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision description of methotrexate tablets 25 mg.
• Side effects other than those listed here may also occur description of methotrexate tablets 25 mg. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome description of methotrexate tablets 25 mg.

What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor description of methotrexate tablets 25 mg. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects description of methotrexate tablets 25 mg.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others description of methotrexate tablets 25 mg.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove description of methotrexate tablets 25 mg.
• Drugs other than those listed here may also interact with methotrexate description of methotrexate tablets 25 mg. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products description of methotrexate tablets 25 mg.

Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read description of methotrexate tablets 25 mg.

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