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leaky gut syndrome methotrexate psariass
(meth oh TREX ate)
Dose Pack, Trexall

What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication leaky gut syndrome methotrexate psariass.
• Methotrexate may cause side effects that could be dangerous or life-threatening leaky gut syndrome methotrexate psariass. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment leaky gut syndrome methotrexate psariass. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others leaky gut syndrome methotrexate psariass. Notify your doctor immediately if you develop any of these symptoms leaky gut syndrome methotrexate psariass.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment leaky gut syndrome methotrexate psariass. Methotrexate is in the FDA pregnancy category X leaky gut syndrome methotrexate psariass. This meansthat it is known to cause birth defects in an unborn baby leaky gut syndrome methotrexate psariass. Methotrexate canaffect a baby both when a woman is treated and when a man is treated leaky gut syndrome methotrexate psariass. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment leaky gut syndrome methotrexate psariass. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment leaky gut syndrome methotrexate psariass.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor leaky gut syndrome methotrexate psariass. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects leaky gut syndrome methotrexate psariass. Discuss the use of aspirin and NSAIDs with yourdoctor leaky gut syndrome methotrexate psariass.
• Do not drink alcohol while taking methotrexate leaky gut syndrome methotrexate psariass.

What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body leaky gut syndrome methotrexate psariass. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others leaky gut syndrome methotrexate psariass. This is how methotrexate works in the treatment of cancerand psoriasis leaky gut syndrome methotrexate psariass. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis leaky gut syndrome methotrexate psariass.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis leaky gut syndrome methotrexate psariass.
• Methotrexate may also be used for purposes other than those listed inthis medication guide leaky gut syndrome methotrexate psariass.

What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease leaky gut syndrome methotrexate psariass.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above leaky gut syndrome methotrexate psariass.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment leaky gut syndrome methotrexate psariass. Methotrexate is in the FDA pregnancy category X leaky gut syndrome methotrexate psariass. This meansthat it is known to cause birth defects in an unborn baby leaky gut syndrome methotrexate psariass. Methotrexate canaffect a baby both when a woman is treated and when a man is treated leaky gut syndrome methotrexate psariass. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment leaky gut syndrome methotrexate psariass. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment leaky gut syndrome methotrexate psariass.
• Methotrexate may be harmful to a nursing infant leaky gut syndrome methotrexate psariass. Breast-feeding is notrecommended during treatment with methotrexate leaky gut syndrome methotrexate psariass.

How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication leaky gut syndrome methotrexate psariass.
• Take oral methotrexate exactly as directed by your doctor leaky gut syndrome methotrexate psariass. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you leaky gut syndrome methotrexate psariass.
• Take each oral dose with a full glass of water leaky gut syndrome methotrexate psariass.
• Methotrexate is also available as an injection leaky gut syndrome methotrexate psariass. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication leaky gut syndrome methotrexate psariass.
• Do not take more of this medication than is prescribed leaky gut syndrome methotrexate psariass. Too much methotrexatecan be dangerous, possibly resulting in death leaky gut syndrome methotrexate psariass. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen leaky gut syndrome methotrexate psariass. Follow yourdoctor's instructions leaky gut syndrome methotrexate psariass.
• It is important to take methotrexate regularly to get the most benefit leaky gut syndrome methotrexate psariass.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects leaky gut syndrome methotrexate psariass.
• Store methotrexate at room temperature away from moisture and heat leaky gut syndrome methotrexate psariass.

What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate leaky gut syndrome methotrexate psariass.

What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected leaky gut syndrome methotrexate psariass.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath leaky gut syndrome methotrexate psariass.

What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor leaky gut syndrome methotrexate psariass. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects leaky gut syndrome methotrexate psariass. Discuss the use of aspirin and NSAIDs with yourdoctor leaky gut syndrome methotrexate psariass.
• Do not drink alcohol while taking methotrexate leaky gut syndrome methotrexate psariass.
• Avoid prolonged exposure to sunlight leaky gut syndrome methotrexate psariass. Methotrexate may increase the sensitivityof the skin to sunlight leaky gut syndrome methotrexate psariass. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable leaky gut syndrome methotrexate psariass.

What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening leaky gut syndrome methotrexate psariass. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment leaky gut syndrome methotrexate psariass. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others leaky gut syndrome methotrexate psariass. Notify your doctor immediately if you develop any of these symptoms leaky gut syndrome methotrexate psariass.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures leaky gut syndrome methotrexate psariass.
• Other, less serious side effects may be more likely to occur leaky gut syndrome methotrexate psariass. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision leaky gut syndrome methotrexate psariass.
• Side effects other than those listed here may also occur leaky gut syndrome methotrexate psariass. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome leaky gut syndrome methotrexate psariass.

What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor leaky gut syndrome methotrexate psariass. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects leaky gut syndrome methotrexate psariass.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others leaky gut syndrome methotrexate psariass.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove leaky gut syndrome methotrexate psariass.
• Drugs other than those listed here may also interact with methotrexate leaky gut syndrome methotrexate psariass. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products leaky gut syndrome methotrexate psariass.

Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read leaky gut syndrome methotrexate psariass.

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