methotrexate ectopic pregnancy investigational

What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate ectopic pregnancy investigational.
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate ectopic pregnancy investigational. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate ectopic pregnancy investigational. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate ectopic pregnancy investigational. Notify your doctor immediately if you develop any of these symptoms methotrexate ectopic pregnancy investigational.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate ectopic pregnancy investigational. Methotrexate is in the FDA pregnancy category X methotrexate ectopic pregnancy investigational. This meansthat it is known to cause birth defects in an unborn baby methotrexate ectopic pregnancy investigational. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate ectopic pregnancy investigational. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate ectopic pregnancy investigational. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate ectopic pregnancy investigational.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate ectopic pregnancy investigational. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate ectopic pregnancy investigational. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate ectopic pregnancy investigational.
• Do not drink alcohol while taking methotrexate methotrexate ectopic pregnancy investigational.

What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body methotrexate ectopic pregnancy investigational. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others methotrexate ectopic pregnancy investigational. This is how methotrexate works in the treatment of cancerand psoriasis methotrexate ectopic pregnancy investigational. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis methotrexate ectopic pregnancy investigational.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis methotrexate ectopic pregnancy investigational.
• Methotrexate may also be used for purposes other than those listed inthis medication guide methotrexate ectopic pregnancy investigational.

What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease methotrexate ectopic pregnancy investigational.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above methotrexate ectopic pregnancy investigational.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate ectopic pregnancy investigational. Methotrexate is in the FDA pregnancy category X methotrexate ectopic pregnancy investigational. This meansthat it is known to cause birth defects in an unborn baby methotrexate ectopic pregnancy investigational. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate ectopic pregnancy investigational. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate ectopic pregnancy investigational. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate ectopic pregnancy investigational.
• Methotrexate may be harmful to a nursing infant methotrexate ectopic pregnancy investigational. Breast-feeding is notrecommended during treatment with methotrexate methotrexate ectopic pregnancy investigational.

How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate ectopic pregnancy investigational.
• Take oral methotrexate exactly as directed by your doctor methotrexate ectopic pregnancy investigational. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you methotrexate ectopic pregnancy investigational.
• Take each oral dose with a full glass of water methotrexate ectopic pregnancy investigational.
• Methotrexate is also available as an injection methotrexate ectopic pregnancy investigational. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication methotrexate ectopic pregnancy investigational.
• Do not take more of this medication than is prescribed methotrexate ectopic pregnancy investigational. Too much methotrexatecan be dangerous, possibly resulting in death methotrexate ectopic pregnancy investigational. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen methotrexate ectopic pregnancy investigational. Follow yourdoctor's instructions methotrexate ectopic pregnancy investigational.
• It is important to take methotrexate regularly to get the most benefit methotrexate ectopic pregnancy investigational.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects methotrexate ectopic pregnancy investigational.
• Store methotrexate at room temperature away from moisture and heat methotrexate ectopic pregnancy investigational.

What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate methotrexate ectopic pregnancy investigational.

What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected methotrexate ectopic pregnancy investigational.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath methotrexate ectopic pregnancy investigational.

What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate ectopic pregnancy investigational. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate ectopic pregnancy investigational. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate ectopic pregnancy investigational.
• Do not drink alcohol while taking methotrexate methotrexate ectopic pregnancy investigational.
• Avoid prolonged exposure to sunlight methotrexate ectopic pregnancy investigational. Methotrexate may increase the sensitivityof the skin to sunlight methotrexate ectopic pregnancy investigational. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable methotrexate ectopic pregnancy investigational.

What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate ectopic pregnancy investigational. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate ectopic pregnancy investigational. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate ectopic pregnancy investigational. Notify your doctor immediately if you develop any of these symptoms methotrexate ectopic pregnancy investigational.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures methotrexate ectopic pregnancy investigational.
• Other, less serious side effects may be more likely to occur methotrexate ectopic pregnancy investigational. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision methotrexate ectopic pregnancy investigational.
• Side effects other than those listed here may also occur methotrexate ectopic pregnancy investigational. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome methotrexate ectopic pregnancy investigational.

What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate ectopic pregnancy investigational. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate ectopic pregnancy investigational.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others methotrexate ectopic pregnancy investigational.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove methotrexate ectopic pregnancy investigational.
• Drugs other than those listed here may also interact with methotrexate methotrexate ectopic pregnancy investigational. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products methotrexate ectopic pregnancy investigational.

Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read methotrexate ectopic pregnancy investigational.

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