methotrexate binding constant
(meth oh TREX ate)
Dose Pack, Trexall
What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate binding constant.
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate binding constant. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate binding constant. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate binding constant. Notify your doctor immediately if you develop any of these symptoms methotrexate binding constant.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate binding constant. Methotrexate is in the FDA pregnancy category X methotrexate binding constant. This meansthat it is known to cause birth defects in an unborn baby methotrexate binding constant. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate binding constant. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate binding constant. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate binding constant.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate binding constant. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate binding constant. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate binding constant.
• Do not drink alcohol while taking methotrexate methotrexate binding constant.
What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body methotrexate binding constant. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others methotrexate binding constant. This is how methotrexate works in the treatment of cancerand psoriasis methotrexate binding constant. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis methotrexate binding constant.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis methotrexate binding constant.
• Methotrexate may also be used for purposes other than those listed inthis medication guide methotrexate binding constant.
What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease methotrexate binding constant.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above methotrexate binding constant.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate binding constant. Methotrexate is in the FDA pregnancy category X methotrexate binding constant. This meansthat it is known to cause birth defects in an unborn baby methotrexate binding constant. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate binding constant. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate binding constant. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate binding constant.
• Methotrexate may be harmful to a nursing infant methotrexate binding constant. Breast-feeding is notrecommended during treatment with methotrexate methotrexate binding constant.
How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate binding constant.
• Take oral methotrexate exactly as directed by your doctor methotrexate binding constant. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you methotrexate binding constant.
• Take each oral dose with a full glass of water methotrexate binding constant.
• Methotrexate is also available as an injection methotrexate binding constant. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication methotrexate binding constant.
• Do not take more of this medication than is prescribed methotrexate binding constant. Too much methotrexatecan be dangerous, possibly resulting in death methotrexate binding constant. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen methotrexate binding constant. Follow yourdoctor's instructions methotrexate binding constant.
• It is important to take methotrexate regularly to get the most benefit methotrexate binding constant.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects methotrexate binding constant.
• Store methotrexate at room temperature away from moisture and heat methotrexate binding constant.
What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate methotrexate binding constant.
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected methotrexate binding constant.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath methotrexate binding constant.
What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate binding constant. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate binding constant. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate binding constant.
• Do not drink alcohol while taking methotrexate methotrexate binding constant.
• Avoid prolonged exposure to sunlight methotrexate binding constant. Methotrexate may increase the sensitivityof the skin to sunlight methotrexate binding constant. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable methotrexate binding constant.
What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate binding constant. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate binding constant. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate binding constant. Notify your doctor immediately if you develop any of these symptoms methotrexate binding constant.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures methotrexate binding constant.
• Other, less serious side effects may be more likely to occur methotrexate binding constant. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision methotrexate binding constant.
• Side effects other than those listed here may also occur methotrexate binding constant. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome methotrexate binding constant.
What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate binding constant. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate binding constant.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others methotrexate binding constant.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove methotrexate binding constant.
• Drugs other than those listed here may also interact with methotrexate methotrexate binding constant. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products methotrexate binding constant.
Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read methotrexate binding constant.
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