methotrexate shortage us
(meth oh TREX ate)
Dose Pack, Trexall
What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate shortage us.
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate shortage us. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate shortage us. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate shortage us. Notify your doctor immediately if you develop any of these symptoms methotrexate shortage us.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate shortage us. Methotrexate is in the FDA pregnancy category X methotrexate shortage us. This meansthat it is known to cause birth defects in an unborn baby methotrexate shortage us. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate shortage us. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate shortage us. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate shortage us.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate shortage us. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate shortage us. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate shortage us.
• Do not drink alcohol while taking methotrexate methotrexate shortage us.
What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body methotrexate shortage us. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others methotrexate shortage us. This is how methotrexate works in the treatment of cancerand psoriasis methotrexate shortage us. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis methotrexate shortage us.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis methotrexate shortage us.
• Methotrexate may also be used for purposes other than those listed inthis medication guide methotrexate shortage us.
What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease methotrexate shortage us.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above methotrexate shortage us.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate shortage us. Methotrexate is in the FDA pregnancy category X methotrexate shortage us. This meansthat it is known to cause birth defects in an unborn baby methotrexate shortage us. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate shortage us. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate shortage us. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate shortage us.
• Methotrexate may be harmful to a nursing infant methotrexate shortage us. Breast-feeding is notrecommended during treatment with methotrexate methotrexate shortage us.
How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate shortage us.
• Take oral methotrexate exactly as directed by your doctor methotrexate shortage us. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you methotrexate shortage us.
• Take each oral dose with a full glass of water methotrexate shortage us.
• Methotrexate is also available as an injection methotrexate shortage us. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication methotrexate shortage us.
• Do not take more of this medication than is prescribed methotrexate shortage us. Too much methotrexatecan be dangerous, possibly resulting in death methotrexate shortage us. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen methotrexate shortage us. Follow yourdoctor's instructions methotrexate shortage us.
• It is important to take methotrexate regularly to get the most benefit methotrexate shortage us.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects methotrexate shortage us.
• Store methotrexate at room temperature away from moisture and heat methotrexate shortage us.
What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate methotrexate shortage us.
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected methotrexate shortage us.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath methotrexate shortage us.
What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate shortage us. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate shortage us. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate shortage us.
• Do not drink alcohol while taking methotrexate methotrexate shortage us.
• Avoid prolonged exposure to sunlight methotrexate shortage us. Methotrexate may increase the sensitivityof the skin to sunlight methotrexate shortage us. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable methotrexate shortage us.
What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate shortage us. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate shortage us. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate shortage us. Notify your doctor immediately if you develop any of these symptoms methotrexate shortage us.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures methotrexate shortage us.
• Other, less serious side effects may be more likely to occur methotrexate shortage us. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision methotrexate shortage us.
• Side effects other than those listed here may also occur methotrexate shortage us. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome methotrexate shortage us.
What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate shortage us. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate shortage us.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others methotrexate shortage us.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove methotrexate shortage us.
• Drugs other than those listed here may also interact with methotrexate methotrexate shortage us. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products methotrexate shortage us.
Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read methotrexate shortage us.
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