methotrexate toxicity
(meth oh TREX ate)
Dose Pack, Trexall
What is the most important information I should know about methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate toxicity.
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate toxicity. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate toxicity. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain, sores in or aroundthe mouth); liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate toxicity. Notify your doctor immediately if you develop any of these symptoms methotrexate toxicity.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate toxicity. Methotrexate is in the FDA pregnancy category X methotrexate toxicity. This meansthat it is known to cause birth defects in an unborn baby methotrexate toxicity. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate toxicity. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate toxicity. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate toxicity.
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate toxicity. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate toxicity. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate toxicity.
• Do not drink alcohol while taking methotrexate methotrexate toxicity.
What is methotrexate?
• Methotrexate interferes with the production and maintenance of DNA, whichis the genetic material in the cells of the body methotrexate toxicity. Methotrexate has a greatereffect on cells that reproduce often such as cancer cells, bone marrow cells,skin cells, and others methotrexate toxicity. This is how methotrexate works in the treatment of cancerand psoriasis methotrexate toxicity. It is not known exactly how methotrexate works in the treatmentof rheumatoid arthritis methotrexate toxicity.
• Methotrexate is used to treat certain types of cancer, psoriasis, andrheumatoid arthritis methotrexate toxicity.
• Methotrexate may also be used for purposes other than those listed inthis medication guide methotrexate toxicity.
What should I discuss with my healthcare provider before taking methotrexate?
• Before taking methotrexate, tell your doctor if you have
· liver disease or a history of liver problems;
· kidney disease;
· alcoholism or alcoholic liver disease;
· an immune system disorder;
· blood or bone marrow problems;
· an infection;
· a stomach ulcer;
· ulcerative colitis;
· diabetes;
· fluid around the lungs or in the abdomen; or
· asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis,or any other lung disease methotrexate toxicity.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring during therapy if you have any of the conditionslisted above methotrexate toxicity.
• Do not take methotrexate if you are pregnant or could become pregnantduring treatment methotrexate toxicity. Methotrexate is in the FDA pregnancy category X methotrexate toxicity. This meansthat it is known to cause birth defects in an unborn baby methotrexate toxicity. Methotrexate canaffect a baby both when a woman is treated and when a man is treated methotrexate toxicity. If thewoman is being treated with methotrexate, pregnancy must be avoided during treatmentand for one ovulatory cycle following treatment methotrexate toxicity. If the man is being treatedwith methotrexate, pregnancy must be avoided during treatment and for 3 monthsfollowing treatment methotrexate toxicity.
• Methotrexate may be harmful to a nursing infant methotrexate toxicity. Breast-feeding is notrecommended during treatment with methotrexate methotrexate toxicity.
How should I take methotrexate?
• Methotrexate should only be administered under the supervision of a qualifiedhealthcare provider experienced in the use of this medication methotrexate toxicity.
• Take oral methotrexate exactly as directed by your doctor methotrexate toxicity. If you donot understand these instructions, ask your pharmacist, nurse, or doctor toexplain them to you methotrexate toxicity.
• Take each oral dose with a full glass of water methotrexate toxicity.
• Methotrexate is also available as an injection methotrexate toxicity. If you are using injectablemethotrexate at home, your doctor will give you detailed instructions regardingpreparation, administration, and storage of the medication methotrexate toxicity.
• Do not take more of this medication than is prescribed methotrexate toxicity. Too much methotrexatecan be dangerous, possibly resulting in death methotrexate toxicity. Methotrexate is used to treatdifferent medical conditions, each with a different dosing regimen methotrexate toxicity. Follow yourdoctor's instructions methotrexate toxicity.
• It is important to take methotrexate regularly to get the most benefit methotrexate toxicity.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with methotrexate to monitor progress and side effects methotrexate toxicity.
• Store methotrexate at room temperature away from moisture and heat methotrexate toxicity.
What happens if I miss a dose?
• Contact your doctor if you miss a dose of methotrexate methotrexate toxicity.
What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected methotrexate toxicity.
• Symptoms of a methotrexate overdose may include nausea, vomiting, bleedingin the stomach, sores in the mouth, blood and bone marrow problems, and possiblydeath methotrexate toxicity.
What should I avoid while taking methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate toxicity. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate toxicity. Discuss the use of aspirin and NSAIDs with yourdoctor methotrexate toxicity.
• Do not drink alcohol while taking methotrexate methotrexate toxicity.
• Avoid prolonged exposure to sunlight methotrexate toxicity. Methotrexate may increase the sensitivityof the skin to sunlight methotrexate toxicity. Use a sunscreen and wear protective clothing when exposureto the sun is unavoidable methotrexate toxicity.
What are the possible side effects of methotrexate?
• Methotrexate may cause side effects that could be dangerous or life-threatening methotrexate toxicity. Discuss with your doctor the risks and benefits of using methotrexate beforestarting treatment methotrexate toxicity. Methotrexate has been reported to cause blood and bone marrowproblems (fever, chills, sore throat, unusual bruising or bleeding, black, bloodyor tarry stools,); lung problems (unexplained shortness of breath, coughing,or wheezing); stomach problems (diarrhea, abdominal pain); sores in or aroundthe mouth; liver problems (yellow skin or eyes, unusual fatigue); kidney problems(blood in the urine; darkened urine, swelling of the feet or legs); and others methotrexate toxicity. Notify your doctor immediately if you develop any of these symptoms methotrexate toxicity.
• If you experience any of the following serious side effects, seek emergencymedical attention or contact your doctor immediately:
· an allergic reaction (shortness of breath; closing of the throat; difficultybreathing; swelling of the lips, face, or tongue; or hives);
· joint pain; or
· confusion, unusual behavior, or seizures methotrexate toxicity.
• Other, less serious side effects may be more likely to occur methotrexate toxicity. Continueto take methotrexate and notify your doctor if you experience
· nausea, vomiting, or decreased appetite;
· itching or a skin rash;
· hair loss;
· boils or acne;
· dizziness;
· increased sensitivity of the skin to sunlight;
· headache;
· drowsiness; or
· blurred vision methotrexate toxicity.
• Side effects other than those listed here may also occur methotrexate toxicity. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome methotrexate toxicity.
What other drugs will affect methotrexate?
• Do not take aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)such as ibuprofen (Advil, Motrin, Nuprin, others), ketoprofen (Orudis KT, Orudis,Oruvail), naproxen (Aleve, Naprosyn, Anaprox), and others except under the directionof your doctor methotrexate toxicity. Although these medications may be prescribed together to treatcertain conditions, methotrexate may interact with aspirin and NSAIDs, and possiblycause serious side effects methotrexate toxicity.
• Before taking methotrexate, tell your doctor if you are taking any ofthe following medicines:
· etretinate (Tegison);
· acitretin (Soriatane);
· theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin,others);
· phenytoin (Dilantin);
· probenecid (Benemid);
· procarbazine (Matulane);
· folic acid or a vitamin supplement that contains folic acid;
· a penicillin antibiotic such as ampicillin (Principen, others), amoxicillin(Amoxil, Trimox, Augmentin, others), dicloxacillin (Dynapen, others), penicillin(Pen-Vee-K, Veetids, others), and others;
· a tetracycline antibiotic such as minocycline (Minocin, Dynacin, others),doxycycline (Vibramycin, Vibra-Tabs, others), tetracycline (Sumycin, others),and others; or
· a sulfa-based medicine such as sulfamethoxazole (Bactrim, Septra, Sulfatrim,Gantanol), sulfisoxazole (Gantrisin), and others methotrexate toxicity.
• You may not be able to take methotrexate, or you may require a dosageadjustment or special monitoring if you are taking any of the medicines listedabove methotrexate toxicity.
• Drugs other than those listed here may also interact with methotrexate methotrexate toxicity. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products methotrexate toxicity.
Where can I get more information?
• Your pharmacist has additional information about methotrexate writtenfor health professionals that you may read methotrexate toxicity.
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